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We also re- view current obstacles to progress in translating basic findings to therapeutic applications, including the need for improved understanding of context-dependent macrophage functions and the myriad factors that regulate mac- rophage phenotype; potential species-specific differences (e.g. humans versus mice); quality control issues; and the lack of standardized procedures and nomenclature for characterizing macrophages.
Context-dependent macrophage functions 79
important to note, however, that the functions of these multiple pheno- types are very context-dependent, and this oversimplification brings its own challenges (discussed in Section 4); thus in this review we use the terms "M1-like" and "M2-like" to describe macrophages that exhibit features of each phenotype.
context-dependent effects of macrophage phenotypes on tissue repair.
Context-dependent macrophage functions
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